Paolo Vignali, PhD

Vignali, P.D.A., DePeaux, K., Watson, M.J. et al. Hypoxia drives CD39-dependent suppressor function in exhausted T cells to limit antitumor immunity. Nat Immunol (2022). https://doi.org/10.1038/s41590-022-01379-9

Ford BR*, Vignali PDA*, Rittenhouse NL, Scharping NE, Peralta R, Lontos K, Frisch AT, Delgoffe GM, Poholek AC. Tumor microenvironmental signals reshape chromatin landscapes to limit the functional potential of exhausted T cells. Sci Immunol. 2022 Aug 5;7(74):eabj9123. doi: 10.1126/sciimmunol.abj9123. Epub 2022 Aug 5. PMID: 35930654. *co-first author https://doi.org/10.1126/sciimmunol.abj9123

Jayaprakash P*, Vignali PDA*, Delgoffe GM, Curran MA. Hypoxia Reduction Sensitizes Refractory Cancers to Immunotherapy. Annu Rev Med. 2022 Jan 27;73:251-265. doi: 10.1146/annurev-med-060619-022830. Epub 2021 Oct 26. PMID: 34699264. https://doi.org/10.1146/annurev-med-060619-022830 *co-first author

Watson MJ, Vignali PDA, Mullett SJ, Overacre-Delgoffe AE, Peralta R, Grebinowski S, Menk AV, Rittenhouse NL, DePeaux K, Whetstone RD, Vignali DAA, Hand TW, Poholek AC, Morrison BM, Rothstein JD, Wendell SG, Delgoffe GM. (2021). Regulatory T cell functional identity is sustained by a glucose:lactate axis that is exploited in the tumor microenvironment. Nature. doi: https://doi.org/10.1038/s41586-020-03045-2

Scharping NE, Rivadeneria DB*, Menk AV*, Vignali PDA, Rittenhouse NL, Ford RB, Ronal P, DePeaux K, Poholek AC, Delgoffe GM. (2021). Metabolic stress induced by continuous stimulation under hypoxia rapidly promotes a terminally exhausted T cell state. Nature Immunology. doi: https://doi.org/10.1038/s41590-020-00834-9.