Laura Molina MD, PhD

Molina L, Zhu J, Trépo E, Bayard Q, Amaddeo G; GENTHEP Consortium; Blanc JF, Calderaro J, Ma X, Zucman-Rossi J, Letouzé E. Bi-allelic hydroxymethylbilane synthase inactivation defines a homogenous clinico-molecular subtype of hepatocellular carcinoma. J Hepatol. 2022 Oct;77(4):1038-1046. doi: 10.1016/j.jhep.2022.05.018. Epub 2022 May 27. PMID: 35636578.

Hu S, Molina L, Tao J, Liu S, Hassan M, Singh S, Poddar M, Bell A, Sia D, Oertel M, Raeman R, Nejak-Bowen K, Singhi A, Luo J, Monga SP, Ko S. NOTCH-YAP1/TEAD-DNMT1 Axis Drives Hepatocyte Reprogramming Into Intrahepatic Cholangiocarcinoma. Gastroenterology. 2022 Aug;163(2):449-465. doi: 10.1053/j.gastro.2022.05.007. Epub 2022 May 10. PMID: 35550144; PMCID: PMC9329208.

Molina LM, Krutsenko Y, Jenkins NEC, Smith MC, Tao J, Wheeler TB, Watkins SC, Watson AM, Monga SP. LiverClear: A versatile protocol for mouse liver tissue clearing. STAR Protoc. 2022 Feb 15;3(1):101178. doi: 10.1016/j.xpro.2022.101178. PMID: 35243370; PMCID: PMC8857608.

Ko S, Kim M, Molina L, Sirica AE, Monga SP. YAP1 activation and Hippo pathway signaling in the pathogenesis and treatment of intrahepatic cholangiocarcinoma. Adv Cancer Res. 2022;156:283-317. doi: 10.1016/bs.acr.2022.02.003. Epub 2022 Mar 9. PMID: 35961703.

Molina L, Nejak-Bowen K, Monga SP. Role of YAP1 Signaling in Biliary Development, Repair, and Disease. Semin Liver Dis. 2022 Feb;42(1):17-33. doi: 10.1055/s-0041-1742277. Epub 2022 Jan 24. PMID: 35073587; PMCID: PMC9372714.

Molina L, Zhu J, Li Q, Pradhan-Sundd T, Krutsenko Y, Sayed K, Jenkins N, Vats R, Bhushan B, Ko S, Hu S, Poddar M, Singh S, Tao J, Sundd P, Singhi A, Watkins S, Ma X, Benos PV, Feranchak A, Michalopoulos G, Nejak-Bowen K, Watson A, Bell A, Monga SP. Compensatory hepatic adaptation accompanies permanent absence of intrahepatic biliary network due to YAP1 loss in liver progenitors. Cell Reports, 2021, Jul 6. PMID: 34233187

Hirsch T*, Pilet J*, Morcrette G*, Roehrig A, Monteiro B, Molina L, Bayard Q, Trépo E, Meunier L, Caruso S, Renault V, Deleuze JF, Fresneau B, Chardot C, Gonzales E, Jacquemin E, Guerin F, Fabre M, Aerts I, Taque S, Laithier V, Branchereau S, Guettier C, Brugières L, Rebouissou S, Letouzé E, Zucman-Rossi J. Integrated genomic analysis identifies driver genes and cisplatin-resistant progenitor phenotype in pediatric liver cancer. Cancer Discovery, 2021, in press. *co-first authors. PMID: 33893148

Bhushan B, Molina L, Koral K, Stoops JW, Mars WM, Banerjee S, Orr A, Paranjpe S, Monga SP, Locker J, Michalopoulos GK. Yap is crucial for CAR-driven hepatocyte proliferation but not for induction of drug metabolism genes in mice. Hepatology, 2020 Aug 13. PMID: 32794202

Ko S, Russell JO, Molina LM, Monga SP. Liver Progenitors and Adult Cell Plasticity in Hepatic Injury and Repair: Knowns and Unknowns. Annu Rev Pathol. 2020 Jan 24;15:23-50. doi: 10.1146/annurev-pathmechdis-012419-032824. Epub 2019 Aug 9.

Bhushan B, Molina L, Koral K, Stoops JW, Mars WM, Banerjee S, Orr A, Paranjpe S, Monga SP, Locker J, Michalopoulos GK. Yap is crucial for CAR-driven hepatocyte proliferation, but not for induction of drug metabolism genes in mice. Hepatology. 2020 Aug 13. doi: 10.1002/hep.31521. Online ahead of print.

Min Q, Molina L, Li J, Adebayo Michael AO, Russell JO, Preziosi ME, Singh S, Poddar M, Matz-Soja M, Ranganathan S, Bell AW, Gebhardt R, Gaunitz F, Yu J, Tao J, Monga SP. β-Catenin and Yes-Associated Protein 1 Cooperate in Hepatoblastoma Pathogenesis. Am J Pathol. 2019 May;189(5):1091-1104. doi: 10.1016/j.ajpath.2019.02.002. Epub 2019 Feb 19.

Molina L, Yang H, Michael AOA, Oertel M, Bell A, Singh S, Chen X, Tao J, Monga SP. Correction: mTOR inhibition affects Yap1-β-catenin-induced hepatoblastoma growth and development. Oncotarget. 2019 Sep 24;10(54):5670. doi: 10.18632/oncotarget.27218. eCollection 2019 Sep 24.

Pradhan-Sundd T, Vats R, Russell JO, Singh S, Michael AA, Molina L, Kakar S, Cornuet P, Poddar M, Watkins SC, Nejak-Bowen KN, Monga SP, Sundd P. Dysregulated Bile Transporters and Impaired Tight Junctions During Chronic Liver Injury in Mice. Gastroenterology. 2018 Oct;155(4):1218-1232.e24. doi: 10.1053/j.gastro.2018.06.048. Epub 2018 Jun 30.

Pradhan-Sundd T, Zhou L, Vats R, Jiang A, Molina L, Singh S, Poddar M, Russell J, Stolz DB, Oertel M, Apte U, Watkins S, Ranganathan S, Nejak-Bowen KN, Sundd P, Monga SP. Dual catenin loss in murine liver causes tight junctional deregulation and progressive intrahepatic cholestasis. Hepatology. 2018 Jun;67(6):2320-2337. doi: 10.1002/hep.29585. Epub 2018 Apr 19.

Molina L, Bell D, Tao J, Preziosi M, Pradhan-Sundd T, Singh S, Poddar M, Luo J, Ranganathan S, Chikina M, Monga SP. Hepatocyte-Derived Lipocalin 2 Is a Potential Serum Biomarker Reflecting Tumor Burden in Hepatoblastoma. Am J Pathol. 2018 Aug;188(8):1895-1909. doi: 10.1016/j.ajpath.2018.05.006. Epub 2018 Jun 18.